The pathogenesis of cerebral circulation disorders caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, impaired neurotransmitter systems, and vascular pathologies that lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia [27]
Novo Nordisk agonist shows strong trial results as MASH cases rise among US adults For the first time, a GLP-1 therapy has been cleared to treat metabolic dysfunction-associated steatohepatitis (MASH), after the US Food and Drug Administration (FDA) granted accelerated approval to Novo Nordisks weight-loss drug Wegovy
Fourth, we confirm the favorable effects of GLP-1 RAs on albuminuria-based outcomes, as shown in clinical trials
doi: 10.2147/CPAA.S374741 137 MahapatraMKKaruppasamyMSahooBM
S.SarrajuA.SandhuA
Reviewed June 2024